Our project: an “artificial pancreas” to fight type 1 diabetes
Currently in France, 200’000 people have Type 1 diabetes, a disease which burden is very heavy. In 2011, some diabetologists launched an artificial pancreas project in order to improve patients quality of life and their regulation of glycemia. Diabeloop SAS was created in 2015 in order to commercialize the final device.The artificial pancreas is composed of three different components to mimic as much as possible pancreas functions. A continuous glucose sensor monitors the patient glycemia and sends data to a smartphone-like terminal, integrating a complex algorithm. This terminal controls a connected insulin pump by ordering the optimal amount of insulin to deliver.
Diabeloop system integrates a telemedicine program, where patient glycemic data is sent. Thus, clinicians have access to patients data to modify treatment as necessary, for an improved long-term regulation.
In 2014, first clinical trials on 35 patients have shown a great success. Diabeloop system is still in development and should hit the market in 2018.
Type 1 diabetes
Type 1 diabetes is an autoimmune disease that affects 200,000 people in France, 30 million worldwide, and can strike anyone. It destroys the specific Pancreas cells that produce insulin, which regulates blood glucose levels. Half of the cases begin before age 20, as young as 1 year old. As a result patients have to manage diabetes their entire life.
To do that, these patients must prick their finger multiple times per day to measure their blood glucose levels, calculate their dose and inject insulin via a special syringe or with a pump.
Too much insulin leads to hypoglycemia, sometimes serious with a coma. Not enough insulin leads to hyperglycemia, which if repeated regularly brings serious complications (blindness, amputations, renal failure, heart diseases).
Every day diabetic patients must…
Calculate their base rates
In particular during the night, with the threat of nocturnal hypoglycemias.
Calculate the amount of insulin for their meals
Sugar and glucose in their meals has to be counted, and translated via a personal factor to a quantity of insulin.
Anticipate any physical activity
By reducing their base rate or take additional sugar. Without this, they will get an hypoglycemic event.
Our project: a connected device mimicking the pancreas function
The project started in 2011 and a prototype was tested successfully on 35 patients in 2014
Fig 1. Example of the evolution of blood glucose in a diabetic patient with the usual treatment
Fig 2. Patient using Diabeloop
University hospital partners
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155 Cours Berriat